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The optimal gene numbers and parameters for drugs in CCLE are listed in Additional file 2. Next, an SVM model was built for each drug after getting the optimal features and model parameters conducted by 10-fold cross validation (Fig. 6).
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Finally, to take into account the uncertainty associated with key model parameters, we conducted a probabilistic analysis as well as several univariate sensitivity analyses; in all scenarios, LAIV was still the dominant strategy.
A sensitivity study on the various model parameters was conducted.
A fully probabilistic sensitivity analysis for all input values to explore uncertainty derived from the model parameters was conducted.
In order to illustrate the use of mathematically informed priors when inferring model parameters we conducted two experiments.
Once the most appropriate model was selected, maximum likelihood estimation of the model parameters was conducted and then the odds ratio and the 95% confidence interval were calculated for each covariate in the model.
Given that the quantity of eligible studies was small for a number of model parameters, in conducting policy evaluations, modelers should be prepared to conduct sensitivity analyses varying those parameters found to be most influential to the study outcomes of interest [ 7- 13, 13- 15, 21, 24, 44].
This paper presents model parameter estimation conducted by data assimilation and associated uncertainty quantification for predictive engineering with specific application to reflood phenomena in PWR rod bundles.
Analysis of Burgers model parameters is also conducted.
An extensive analysis of sensitivity to key model parameters is also conducted to describe the model capabilities.
Moreover, uncertainty characterization of the SF model parameters was also conducted to analyze the effect of each parameter on model performance.
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