We performed two simultaneous runs of Metropolis-coupled Markov chain Monte Carlo (MCMC) analysis with the substitution model parameters, each comprising four chains and 10 million generations.
Based on the results of the first multivariate linear regression analysis of four pre-defined models, ten individual parameters comprising gender, DM duration, type 2 DM, retinopathy, body mass index, rate pressure product, triglyceride, glycoalbumin, albuminuria and F-wave latency were chosen for the final multivariate linear regression analysis (Table 4).
Firstly, the results of this experimental study serve to identify the material parameters comprised in the model.
Multiplicative parameters comprise all other parameters we considered, most prominently maximal conductances of currents.
All other model parameters are identical to the microbial community model (comprising the A, SS and FS types) described in the main article.
We simulated four different read data sets, comprising a set of different model parameters, each by sampling 10 000 reads from the human reference genome.
First we describe the training data, comprising rare variants of known pathogenic/benign status, which will be used to estimate model parameters.
The SDEs in Equation (3) comprise three types of tunable parameters: ODE model parameters, elements of the matrix and elements of the set of measurement covariance matrices, and we denote the set of all potential parameters by.
The subsequent methodology to develop and validate virtual subjects and each virtual population comprised three key steps: 1. Parameter exploration: Variability in key model parameters was explored to generate alternate parameterizations, each of which represents a potential virtual subject.
Hypotheses expressed in terms of model parameters were assessed at each voxel with univariate statistics, yielding an image whose voxel values comprise a statistical parametric map [22].
