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Second, an optimal training model parameter set was determined using two-step cross-validation.
Nevertheless, finding the good model parameter set to fit membrane voltage recordings is often a very time-consuming and complex task, difficult to achieve manually.
The CT-MMAE is composed by a dynamic weighting signal generator and a bank of local continuous-time observers where each observer is designed using one element of a finite discrete model (parameter) set.
The top right panel shows that the order of the importance of parameters (for this particular model parameter set) is as follows: log, log |A|), log z), log(L), and log(Y).
The top right panel shows that the order of the importance of parameters (for this particular model parameter set) is as follows: log, log |A|), log(L), log(Y), and log z).
To estimate model parameter set θ containing {W, Ψ}, the expectation maximization (EM) algorithm is used, which is an iterative method proposed for maximum likelihood of a latent probabilistic model (Dempster et al. 1977, Moon 1996).
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The model parameter setting for the wildtype simulations as well as for the simulations of mutants are given in Table 1 and Table 2.
Results of the base-case and sensitivity analyses were recalculated 5000 times, with all model parameters set simultaneously, each selected at random from the respective parameter distribution.
The framework was tested on the Randstad region in the Netherlands, identifying 77 model parameter sets that generated a Pareto front of optimal trade-off solutions between the objectives.
Multiple natural history model parameter sets are assumed to act concurrently on the colon and parameter set prevalence combinations, whose a priori likelihoods are a function of patient sex, provide a basis set for patient-level predictions.
Instead, we estimated a family or ensemble of probable model parameter sets [36] [38] using a Multi-Objective Thermal Ensemble (MOTE) technique (materials and methods).
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