This was the one based on Undead's original concept, a model of overload derived from the Winter Jazzfest, which is presented by the same promoters.
Open image in new window Fig. 2 Model of overload protection action.
In this model, calcium overload is observed in the arterial wall, in the heart, and in the kidneys leading to the impairment of their function [ 2].
This hypothesis has been challenged in situ (7, 20, 21, 32), in genetic models following overload (39), following acute resistance type contractions (15, 41), and in wild-type mice following overload (30).
The protein overload model is a conceptually simple, clear and direct model [ 5, 6] to demonstrate the pathogenicity of proteinuria.
The different models were chosen as models of continuous overload (PLN and SOL) with (PLN) or without (SOL) changes in recruitment and an intermittent overload model (EDL).
Moreover, adenoviral gene delivery of dominant negative JNK in a rat model of pressure overload hypertrophy abolished the increase in BNIP3 expression in response to pressure overload.
This change in GHR expression is consistent with previous reports of decreased GHR mRNA in a compensatory overload model [ 29], and fiber-type specific increased GHR mRNA in a hindlimb suspension model of muscle atrophy [ 30].
Although we did not test PPARα agonists in our protein overload model in rats in vivo, we did demonstrate the protective role of PPARα agonists in an in vitro model of PTCs that were incubated with high doses of albumin and showed that PPARα agonists regulate megalin expression in vivo in mice.
In the case a simulation model of an overload clutch was developed by a design engineer who was already familiar with the C&C2-Approach.
