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The model output chart (Figure 3) indicates that the cost-effectiveness of HMM using CQ+SP from the provider perspective varies with malaria transmission and the probability that a child would receive appropriate care.

This prediction is verified by the corresponding truncations, and by simulations comparing the original and the reduced model output (see Figure 4).

A function for the synaptic ribbon that is suggested by the model outputs (see Figure 8) is that the purpose of tethering vesicles onto the ribbons surface is not to convey them to the presynaptic membrane but instead to keep the vesicles close enough so as to fuse.

On the other hand, it is not possible to neglect even a small portion of the weak sites without visible reduction in the model output quality (see Figure 7 in [ 5]).

Note that the values chosen for IVThalf and S are conjectures based on the "good" model output shown in Figure 8: (13) Fused     Vesicles = FV max ⁡ − 1 1 + exp ⁡ (IVT half − IVT / S ).

These experimental results, together with model output, are shown in Figure 4C.

The curves are given as Additional file 1 and Additional file 2 and are strikingly concordant with the model outputs illustrated in Figures 3 and 4. The effects of treatment and strain on Hsp gene expression levels are evident whether considering modeled or raw data.

Regulator inputs and model output are shown as in Figure 2. (B ) and (C ) The stripe is still sharply defined when the anteriormost region is excluded.

As reported in Table 6 and illustrated in Figure 7, model output predicts that increasing the KdADP from 43.0 to 79.4 μM due to ANT1 Lys23 acetylation would result in a dramatic decrease in mitochondrial ATP export.

Regulator inputs and model output are shown as in Figure 2. (A C ) The linear logistic model with Hb, kni and tll does not produce as sharp borders as the models in Figure 4. DOI: http://dx.doi.org/10.7554/eLife.00522.014 10.7554/eLiFigure22.015 Figure 4 figure supplement 3. Consistency of the eve 3+7 linear and quadratic models.

Regulator inputs and model output are shown as in Figure 2. (A C ) The linear logistic model with only Hb and kni does not repress expression to the posterior of stripe 7. DOI: http://dx.doi.org/10.7554/eLife.00522.013 10.7554/eLiFigure22.014 figure 4—figure supplement 2. A linear logistic model with Hb, kni and tll does not have sharp stripe borders.

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