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Humans are believed to be more sensitive to the toxic effects of arsenic than are model organisms; therefore it is important to understand the exposure implications on a genomewide scale (Mead 2005).
Since the common conception of a model organism is changing along with technological advances in genome sequencing and editing, it is difficult to provide a complete list of model organisms; therefore, here we mainly focus on the canonical set of model organisms defined by the National Institutes of Health (NIH) during the 1990s.
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This model organism may therefore be well-suited to investigating regulation by IrrE.
The focus on a handful of genetic backgrounds of this important model organism may therefore provide an incomplete view of eukaryotic physiology.
These source databases are also extensively used by investigators utilizing the various model organisms and are therefore familiar to users.
Fungi are therefore good model organisms for studies of how and why a particular mode of reproduction is selected.
It is noteworthy that the predominant fraction of investigations on the stress response have largely (but not entirely) been previously performed on a small number of model organisms in the laboratory and, therefore, have limited value in an ecological context.
Stream-living juvenile salmonids are well suited for performing experiments relating to prior residency, and have therefore become important model organisms in this context.
These organisms therefore represent a model system to understand how pathogens evolve over time, as well as present the opportunity to examine pressures that drive selection for HGT events.
Therefore, insights from model organisms, such as Drosophila, the simplest (genetic) model system with a heart (Bier & Bodmer, 2004), will likely provide valuable clues for understanding the cellular and molecular mechanisms involved in cardiac aging (Dai et al., 2010; Nishimura et al., 2011).
Therefore, studies on multicellular model organisms help to decipher how Cdc48-dependent proteolysis is regulated in time and space to meet developmental requirements.
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