Although the supramolecular organization of the respiratory chain complexes has been extensively documented in different model organisms, the existence of factors mediating respirasome assembly or their stabilization have remained elusive (Schägger and Pfeiffer, 2000, 2001).
Consider one of biology's favorite model organisms, the millimetre-long roundworm Caenorhabditis elegans.
These are not to be confused with model organisms: The latter is a biological species that is being bred in the laboratory for experimental work.
Prompted by the clues from model organisms, the architecture of the functional ATG7-mediated regulatory network has been explored in the settings of human biology and disease, such as cancer, infectious disease, and neurodegenerative diseases (Fig. 1).
Here, we sought to validate an experimental design to accurately predict the time of death by analyzing the expression of hundreds of upregulated genes in two model organisms, the zebrafish and mouse.
In model organisms, the impact of heterozygosity can be tested directly with engineered mutant alleles or in a hemizygous state where the expression of one allele is abrogated completely.
Over decades, researches on aging have revealed the retardation of physiological decline and lifespan extension are conceivable by genetic perturbations in model organisms, the results now offered potential therapeutic strategies to prolong both healthspan and lifespan (Lopez-Otin et al., 2016).
For eukaryotic model organisms, the limitation of group II intron function by low Mg2+ concentrations can be overcome by injecting additional Mg2+ or Mg2+ in combination with polyamines.
Such a mis-classification of co-orthologous proteins as orthologous could lead researchers to compare, across different model organisms, the downstream effects of proteins that have different functions.
Here, we analyze respectively, the abundance and the pair-wise domain-domain co-occurrences of 25 domains found in well-documented CM proteins in 5 model organisms: the yeast Saccharomyces cerevisiae, the worm Caenorhabditis elegans, the fly Drosophila melanogaster, the mouse Mus musculus and the human Homo sapiens.
Therefore, to identify potential target proteins for new avenues of drug discovery we have taken a comparative chemogenomics approach utilizing the putative proteome of Schistosoma mansoni compared to the proteomes of two model organisms, the nematode, Caenorhabditis elegans and the fruitfly, Drosophila melanogaster.
