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Using Clustal Omega [ 109], homologs were then aligned against all known RNAi proteins from the five model organisms on a per-protein basis.

Hence, the CellFinder platform provides a framework for comprehensive descriptions of human tissues, cells and commonly used model organisms on molecular and functional levels, in vivo and in vitro.

In the present study, we assume the evolutionary order of model organisms on the basis of the evolutionary distances from the viewpoint of humans, as described previously [ 18, 19].

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The nematode Caenorhabditis elegans is a model organism on which such an analysis can be performed, as its entire neuronal wiring layout has been completely mapped [2].

The planarian Schmidtea mediterranea (figure 3g ), which is easily and cheaply maintained in the laboratory, is the only multicellular model organism on our list with an external multiciliated epithelium.

In light of the impact of the evolution of the EARS on African hydrographic systems and the dependence of our model organism on these systems to disperse, we expect a deep phylogenetic separation between viviparid species east and west of the western branch of the rift system.

The isolation of fast evolving genes can be easily accomplished on model organisms for which abundant genomic and transcriptomic knowledge exist.

The zebra finch is one of the prime model organisms for studies on vocal communication, especially with regard to song.

Here, we discuss the application of these methods to model organisms, focusing on the zebrafish Danio rerio, which provide unique biological contexts for the analysis of RBPs and their functions.

Tissue specific analysis can thus be performed in analogous tissues using a wide variety of model organisms, concentrating on these highly conserved genes.

To account for false negatives (Phase 2), interactions were added to the network by inferring relationships that are precedented in model organisms based on protein family relationships.

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