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One approach to quantifying cis and trans regulation in model organisms involves assaying gene expression in two parental lines compared to allele-specific expression (ASE) in the hybrids (Wittkopp et al., 2004) and asking whether alleles are regulated differently in the parentals compared to the hybrids.
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Other issues relevant to the representation criterion include how the use of model organisms constitutes an example of case-based reasoning (Ankeny 2012) and how model organisms involve idealizations or known departures from features present in the model's target as the result of laboratory cultivation (Ankeny 2009).
FORWARD genetics in model organisms, which involves random mutation and isolation of a phenotype, laid the foundation for characterization of gene function.
Modeling an organism involves two conceptual steps: gathering of data to create a recipe for the model, and use of this recipe to build a virtual model.
Comparing expression-level categories between organisms involves considerable uncertainty.
This geographic repeatability and the fact that a model organism is involved, gives the musculus-domesticus contact zone the potential to play a central role in understanding the general features of secondary contact and the nature of barriers to gene flow between taxa, and in particular the action and nature of 'speciation' genes associated with sex chromosomes.
In the past decade, a large amount of genomic information had been compiled from a number of organisms involving several model plants.
This paper expands the description of biological processes by introducing models of ecophysiological phenomena of the organisms involved.
Although issues of ascertainment bias have been addressed extensively in human data, studies of non-model organisms often involve deeper divergences among sampled populations.
The piRNA pathway has been shown in model organisms to be involved in silencing of transposons thereby providing genome stability.
They include genes nominated based on observations of lifespan extension in model organisms; and genes involved in lipid metabolism, immune response and inflammation, stress response, and others.
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