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Loss-of-function genetic screens in model organisms have elucidated numerous biological processes, but the diploid genome of mammalian cells has precluded large-scale gene disruption.
Studies in human cells and model organisms have begun to reveal the mechanisms of microRNA activity, and the wide range of normal physiological functions they influence.
As we have seen, model organisms have greatly shaped the development of experimental biology, and continue to do so.
Biochemical, molecular, and physiological studies using cancer cell lines or model organisms have established the current paradigm of the Mediator functions.
Intense genetic studies on model organisms have cast light on the processes of morphological development, cell differentiation, and the control mechanisms governing organ (re generation.
Model organisms have proven highly valuable in understanding epigenetic mechanisms of gene regulation [21].
Mutation screens in model organisms have helped identify the foundation of many fundamental organismal phenotypes.
A few model organisms have been used to explore the physiological role of FLCN.
Various model organisms have been utilized to understand the molecular mechanisms of cardiac hypertrophy, each having its advantages and disadvantages.
Mutation screens in model organisms have uncovered the building blocks of many fundamental phenotypes [reviewed in 1], [2], [3].
Significantly, studies in model organisms have additionally shown that some MSC are derived from the neural crest [13], [14].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com