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For these reasons, the present study extends the "road-map" for applications of DNA microarrays to studies of non-model organisms described by Gracey et al. [ 12] and later by others (reviewed in [ 13, 14]), by characterizing the response of this critical aquatic indicator species to environmental stress.

In one review [ 28], the results of susceptibility loci studies were also mentioned, and in another [ 29], gene expression studies in man and model organisms were described and discussed.

Previous research across numerous model organisms has described evolutionarily conserved responses to stresses such as food deprivation, heat shock, and various forms of toxicity (reviewed in Lant and Storey 2010).

Previous studies in several model organisms have described many aging-related phenotypes, including morphological changes, accumulation of oxidatively damaged DNA and proteins, shortened telomeres, enriched extra-chromosomal rDNA circles (ERCs), etc. (reviewed in Sinclair et al., 1998; Balaban et al., 2005; Kirkwood, 2005; Lombard et al., 2005).

The essential principles of its inheritance traits are known nowadays thanks to the pioneering research conducted by Thomas Morgan [ 94], while various characteristics of Drosophila melanogaster as a model organism were described in [ 95– 95].

Mimicry is commonly thought to involve the resemblance of one organism (described as the mimic) to another organism (described as the model), the physical similarity adopted by the mimic, a mechanism to deceive a third organism [ 77- 79].

Yet, model organisms can not fully describe and represent a whole evolutionary branch.

Collembola have been described as model organisms in Antarctic terrestrial ecosystem studies, on account of the extent of existing biochemical and ecophysiological research, and their dominant role in Antarctic terrestrial ecosystems [ 12].

Position effect mechanisms, first discovered and described in model organisms, remain poorly investigated in human pathology.

We suggest that human emNCSC resemble cephalic NC described in model organisms.

Buffering has been described in model organisms.

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