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Treatment decisions are, and should be, based on controlled studies on humans, not on theory or on experiments performed on model organisms alone.
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Although global quantification of mRNA levels is often more convenient, several studies have reported that for human cells and model organisms RNA levels alone are not uniformly predictive of protein levels (Gygi et al., 1999; Vogel et al., 2010; Maier et al., 2011; Nagaraj et al., 2011; Schwanhausser et al., 2011).
If external hazards are excluded, aging alone determines the mortality in a population of model organisms.
Many of them are important model organisms.
Hedges, S. B. The origin and evolution of model organisms.
Shaffer, H. B. Phylogenetics of model organisms: The laboratory axolotl.
In model organisms, Gli3 integrates Hh and Wnt function.
"Life extension in model organisms may be an artifact to some extent," they wrote.
Consider one of biology's favorite model organisms, the millimetre-long roundworm Caenorhabditis elegans.
Use of lignocellulolytic organisms alone at high temperatures could potentially reduce the cellulase requirement.
Model organisms include yeast Saccromyces cerevisae and fly Drosophila melanogaster.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com