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We hereby propose zebrafish as a model organism based on the premise of its comprehensive similitude with the mammalian brain.
Nevertheless, selection of a model organism based on accumulated technical experience and on availability of experimental techniques does not guarantee representative results in other organisms.
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To account for false negatives (Phase 2), interactions were added to the network by inferring relationships that are precedented in model organisms based on protein family relationships.
We attempted to reconcile interactomes from multiple model organisms based on two different approaches: orthology [ 23] and interaction network topology techniques [ 24].
Many founding members of the SUN and KASH domain protein families have initially been identified in model organisms based on mutant phenotypes affecting nuclear anchorage or migration.
Several databases have been constructed for gene coexpression in model organisms based on a large amount of publicly available gene expression data measured by GeneChip platforms.
Here we have predicted PPI in human and four commonly used model organisms based on orthology to proteins involved in known interactions within these five species.
We have set up a pipeline to predict MXE candidates in the whole genomes of several model organisms based on conserved splice sites, same reading frame, sequence similarity and similar length.
Our aim is to facilitate annotation of assembly products, allowing users to retrieve sequence data from these emerging model organisms based on similarity to known genes or predicted function.
Several landmark studies have been published in the last few years on the chromatin structure of model organisms based on the analysis of genome-wide nucleosome maps (Albert et al., 2007; Field et al., 2008; Mavrich et al., 2008a, b; Ponts et al., 2010; Shivaswamy et al., 2008; Valouev et al., 2008; Zhang and Pugh, 2011).
The number of UniGen matches against the UnipProt database found in other transcriptome studies of non-model organisms based on the 454/Roche platform is roughly similar to the 5380 meta-assembly matches detected in this study, at a cutoff value of < e-5 (e.g. [ 11] Melitaea cinxia: 6122 at < e-5 ).
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