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Moreover, the results of split-sample validation (see Additional file 2) showed that the CRT model optimally fits the data, supporting its external validity.The sensitivity analyses excluding fetal distress and dystocia yielded some differences in the variables discriminating the sub-groups at increased risk of CD.
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A three-pool (active, slow, and passive) C-cycling model was optimally fitted with 376 published laboratory incubation data from soils acquired from 73 sites with mean annual temperature ranging from − 15 to 26 °C.
Exploratory SEM established the interregional covariances of activity to define their directionality and strength for connectivity models generated from the four regions of interest (ROI) (FP, PCC, pSTS, and rACC) comprising the constrained anatomical model that optimally fit data from each of the three conditions (neutral, care, and justice).
All three resulting clade-specific diversification models were optimally fit as Yule models (AIC = 339.3032).
The case studied in this paper shows one example in which model parameters that optimally fit the data are not necessarily the best ones from a biological point of view.
However, it is crucial to choose an adequate experimental model and use imaging technology that optimally fits with the chosen methods and properties of the sample.
On average, the difference between predictive performance of internally and externally validated SF-models is not large with optimally fitted models (Table 2).
However, it is important to point out the limitation of simulation experiments in such an emulative study - the optimally fitted model would depend on the choice of the generative model.
In order to use the model optimally, it is necessary to map its functional entities.
The blue lines are data measured in the experiment and the orange lines are theoretical predictions based on the SLH model for the CCD with optimally fitted parameter values.
In model refinement, XVOLs and a molecular shape constraint derived from the highly active compound 1 in its conformation that optimally fit the highest ranked model were added as steric restrictions.
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Justyna Jupowicz-Kozak
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