Finally, we demonstrate that the overhead associated with block-oriented modeling only minimally increases model instantiation times, and need not adversely impact solver behavior.
Additional limitations of the PheWAS approach include the high-throughput manner in which phenotypes are defined, and that regression models are only minimally adjusted for standard covariates.
Furthermore it was found that more complex models explained only minimally additional variance [ 3]. iii The algorithm is available from the HERC website iv See [ 17] for further details on HODaR.
Notably, adding KIM-1 to interleukin (IL -18 [AUC for IL -18for progressive AKI 6 h after inclusion was 0.87 (CI 0.80–0.93)] in a predictive model improved the model's accuracy only minimally [AUC 0.88 (CI 0.82–0.93)].
The expression profiles of solid tumor models in rodents have been only minimally studied despite their extensive use to develop anticancer agents.
In contrast, mutation of D178, which was predicted to contribute to BH BH dimer formation only minimally in our model, did not diminish p85α homodimerization.
Although it has been shown to be effective as a single agent in pre-clinical models of neuroblastoma, bortezomib is not only minimally effective in the treatment of various other solid tumours but also has been associated with toxic side effects when administered as a single agent.
Unlike other reported HED-causing mutations in the TNF domain which were expected to affect the receptor binding site or overall structure of the EDA protein, molecular modeling suggests that these two mutations only minimally affect the stability of EDA trimer.
As the mean X-chromosomal admixture fraction is generally near its limit for g in this range, both in the single-admixture model and in the constant-admixture model, the specific g ∈ [ 14, 20 ] only minimally changes the results.
In comparison, the normalization carried out by the model needs only one array and it alters only minimally the overall distribution of the log of the original data.
