In a rabbit model of ventilation-induced lung injury, pre-treatment with metformin was associated with a reduction of lung edema and histologic lesions.
In terms of agricultural dairy buildings, the modelling of ventilation rates may involve in several variables, including the opening sizes at side walls and the outdoor wind conditions.
Models of ventilation-induced lung injury have shown that ventilation of normal or lavaged lungs with low end-expiratory lung volume causes a persistent increase in airway resistance and histological evidence of peripheral airway injury characterized by bronchiolar epithelial necrosis and sloughing and rupture of alveolar-bronchiolar attachments [ 9- 13].
We have developed a murine model of mechanical ventilation in endotoxemic animals, in which neither mechanical ventilation by itself, nor LPS by itself, results in lung or end-organ injury, but in which the combination of LPS with mechanical ventilation results in end-organ injury.
Therefore we sought to compare the functional and structural effects of intratracheal application of Gram-negative and Gram-positive bacterial products to ventilated lungs in a mouse model of mechanical ventilation.
We tested the hypothesis that ropivacaine attenuates lung injury/inflammatory hyper-permeability in the mouse induced by either high tidal volume (HTV) ventilation or bacterial endotoxin alone, versus the "double-hit" model of HTV ventilation together with bacterial endotoxin [ 6].
We therefore aim to investigate the effects of lower tidal volumes (5 and 7 ml/kg) compared to the commonly used tidal volume of 10 ml/kg without and with addition of PEEP and compared to spontaneously breathing animals in a mouse model of mechanical ventilation.
p. 1421 9)., we develop a simple prediction model for this natural ventilation potential applicable to Chinese residential buildings, using a simple analytical model of natural ventilation considering the combined effect of wind and thermal buoyancy forces.
