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We refer to the scheme presented herein as the non-proportional model of vaccination because the administration of vaccines depends on a daily limit, rather than on a proportion of the population.
We refer to our model as the non-proportional model of vaccination, since the administration of vaccines is limited by a daily maximum number rather than a proportion of the population, and compare the results to those obtained when vaccination is implemented using a proportional scheme.
These approaches shed light on the cellular fate of Aβ in a simulated cell-based model of vaccination, supporting cellular mechanisms of amyloid presentation in current and future vaccine development.
Fortunately, the problem was overcome through the application of a model of vaccination counseling involving most parents on the choice of the quadrivalent or monovalent vaccine since the first dose.
We have investigated the fate of amyloid as a model antigen in a cellular model of vaccination.
This model of vaccination, while highly successful for some diseases, is problematic for others.
Similar(48)
The key observation prompting the development of the model presented here was that most existing models of vaccination of which we are aware distribute vaccines based on a proportion of the eligible population [ 31- 40, 43- 48].
Initially, to compare the proportional and non-proportional models of vaccination we assumed that the daily limit was 106 vaccines (a value corresponding to 1% of the population).
We also evaluated the use of in vivo electroporation to deliver these vaccines to overcome the immunogenicity barrier encountered in larger animal models of vaccination.
This raises the possibility that we can improve mouse models of vaccination and immunity by selective microbial exposure of laboratory animals to mimic that of humans.
Therefore, it is unclear from these studies as to the conformation of short-chain amyloidogenic species, whether identified intracellularly or deposited extracellularly in simulated animal or cell-based models of vaccination.
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