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We have also tested a two-parameter, phenomenological model of tracer movement used by Backes et al. [16].
The time course of activity in the region was modelled as the sum of the blood-sampled input function and a compartmental model of tracer uptake in the surrounding tissue.
This work identifies an appropriate model of tracer movement, then uses the model to simultaneously estimate arterial input functions for bolus injections of FLT from TACs of carotid artery regions drawn on dynamic FLT-PET images.
A one-compartment model of tracer movement to and from the artery best described uptake in the tissue surrounding the artery, so the final model of the input function and tissue kinetics has nine parameters to be estimated.
Input functions for FLT-PET studies of the head and neck can be estimated well using a one-compartment model of tracer movement and TWO blood samples obtained after the peak in arterial activity.
Accurate descriptions of arterial input functions, delivered by bolus injection, can be obtained for FLT-PET through simultaneous estimation using a one-compartment model of tracer movement to and from the artery and two blood samples, taken at intermediate (2
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Here, mathematical and numerical modelling of tracer and contaminant migration in variably saturated fissured chalk is presented, considering the aforementioned conceptual model.
Using laboratory column experiments with both single media and layered-media columns and computer modeling of tracer breakthrough results, we examined the difficulty that layering poses to subsurface remediation and characterization techniques.
Therefore, specifically in PET studies where absolute uptake quantification is necessary (e.g. kinetic modelling of tracer uptake in the brain), the headphones should be avoided.
Robust quantitative analysis in positron emission tomography (PET) and in single-photon emission computed tomography (SPECT) typically requires the time-activity curve as an input function for the pharmacokinetic modeling of tracer uptake.
Using "best-fit" parameters derived from kinetic modeling of tracer 89Zr-J591 (i.e., 60 μg/mouse), the TACs for higher doses up to 2000 μg of 89Zr-J591 were obtained to determine the correlation between predicted TACs generated via kinetic modeling and empirically measured TACs.
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