Sentence examples for model of thymic from inspiring English sources

Our model of thymic epithelial senescence is based on data obtained with mice undergoing physiological senescence.

This has led to the structure-led model of thymic involution, where epithelial-originating changes drive involution 20– 20.

These features demonstrate an anatomical disparity between the FVB/N and C57BL/6 strains present during early development, consistent with a structure-led model of thymic involution.

Together, these results support the structure-led model of thymic involution, whereby the degradation of the architectural integrity of the thymus leads to reduced function.

The structure-led model of thymic involution would predict these two phenotypes to be causatively linked, with the development of epithelial voids breaking the connection between thymic epithelial cells and the VAP-1+ vasculature required for the entry of BM-derived precursors 27, 28.

Intrathymically infusing young WT mice with exogenous TAp63 cDNA induces TEC senescence, whereas blockade of TEC differentiation via conditional FoxN1 gene knockout (a model of accelerated thymic aging) accelerates the occurrence of this phenotype to early middle age.

Open image in new window Figure 1 A model for thymic development and selection of Treg.

IGF-1 also regenerates the thymus in a rat model of dexamethasone-induced thymic atrophy [38].

Furthermore, in a model of age-related, chronic thymic involution, investigators compared rapidly-involuting strains of mice with slowly-involuting strains of the same age.

These results demonstrate that Bim and Bad have overlapping roles as tumour suppressors, at least in this model of γ-irradiation-induced thymic lymphomagenesis.

These results show that Rac1 depletion in both mouse models leads to the loss of thymic epithelial cells and destruction of the normal thymic architecture.