Sentence examples for model of tau from inspiring English sources

He has used new imaging technologies to map — for the first time — the three-dimensional atomic model of tau tangles inside the brain, as published in 2017 in the journal Nature.

Moreover, in a transgenic mouse model of tau pathology, we observed that isoflurane-induced hypothermia accelerates neurofibrillary pathology [17].

The first in vivo model of tau propagation showed a similar induction of tau pathology.

A suitable animal model of tau mis-splicing to evaluate SMaRT in neurons is the htau mouse.

Based on these observations and a computed cross-section of PHF (Fig.  1k) [ 1], we propose a schematic model of tau folding in PHF (Fig.  1l).

Tau poly-ubiquitination is acknowledged to be a late process in the pathogenesis of Alzheimer's disease and in an animal model of tau pathology [48,49].

We found that the MAPTP301SPS19 mouse model of tau-dependent neurodegenerative disease10 accumulates p16INK4A-positive senescent astrocytes and microglia.

In summary, the high prevalence of downregulation of synaptic-related genes indicates that the moderately aged hTau mouse may be a model of tau-induced synaptodegeneration, and has profound effects on how we perceive progressive tau pathology affecting synaptic transmission in AD.

This commentary will discuss the use of immunotherapy for AD, focusing on tau immunotherapy in the context of recent reports on the use of tau phospho-peptides in transgenic models of tau pathology.

In animal models of tau protein, such as P301Stau transgenic mice, someone found that there gathered a large number of reactive microglia surrounding tau protein nerve cells [ 37].

To conclude, until now, only in vivo models of Tau capture [ 12, 48] and/or Tau secretion have been developed [ 21].