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In a murine model of stem cell gene therapy for X-CGD, the chimeric vector resulted in high levels of gp91phox expression in committed myeloid cells and granulocytes, and restored normal NADPH-oxidase activity.
In the present study we introduced a simple few-parameter model of stem cell and progenitor population dynamics that is explicitly based on noise regulation.
In this paper we shall use a computational model of stem cell differentiation to explore the molecular basis of cell fate specification and reprogramming by defined factors.
MSC embedded in 3D type I collagen gels were used as a model of stem cell osteogenic differentiation and tissue remodeling [30].
We used human mesenchymal stem cells (MSC) embedded in 3D type I collagen gels as a model of stem cell osteogenic differentiation and tissue remodeling [30].
We have generated a computational model of stem cell fate regulation by the CLV3/WUS circuitry in the shoot apical meristem.
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This review provides a perspective of both these cell types and discusses potential models of stem cell growth and propagation.
The proliferation of models of STEM that exist and the associated lack of practical advice creates general confusion about integrated STEM that requires clarification, especially for teachers charged with implementing integrated STEM in classrooms (Bybee, 2010).
These various models of STEM education, however, do not necessarily provide teachers with details regarding instructional strategies that answer the question: what does integrated STEM look like in the classroom?
These findings are broadly consistent with previous research that showed significant improvements in LiDAR models of stem volume through addition of stand density as an explanatory variable (Watt and Watt 2013; Watt et al. 2013).
For example, in models of stem cell clones, stochastic 'voter' or 'random walk' models of neutral drift converge to 'universal' patterns which obey Taylor's law with b = 2 for 'any mechanism of stem cell self-renewal, however complex' (Klein and Simons 2011, page 3107).
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