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To measure the strength of natural selection in this step, we used a Gaussian model of stabilizing selection, following Lande (1976) and Ford (2002).
This so-called "mean-reverting" process has been used as a model of stabilizing selection since deviation away from the phylogenetic mean is penalized under maximum likelihood reconstruction.
Numerical results of Charlesworth (2013) demonstrate that a significant pressure of selection is created even when the difference between the mean value of a trait and its optimum is small under a model of stabilizing selection.
This reconstruction for Afrotheria seems unlikely and may lead us to suppose that a single phylogenetic mean for the entire Eutheria does not form a realistic model of stabilizing selection.
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Further, alternative models have been proposed that incorporate explicit models of stabilizing or strong directional selection [e.g.], [48], [49,50].
Most theoretical approaches to adaptation in a changing environment are based on models of stabilizing selection with a moving optimum.
However, recent theoretical models of stabilizing selection predict that if sufficient mutational bias exists to alter the population mean of a quantitative trait away from its optimum value, the intensity of selection is nearly independent of N e (Charlesworth 2013).
Instead, our work provides empirical observations that are consistent with recent models of stabilizing selection causing codon usage bias and support a mechanism for preference of GC-ending codons in an AT-rich mutational background.
Recently, Charlesworth (2013) developed analytical approximations for parameters of interest in a model of interacting stabilizing selection, mutational bias and drift.
This paper is concerned with the design of stabilizing model predictive control (MPC) laws for constrained linear systems.
In a series of patients with large varus deformities and medial compartment osteoarthritis, treated with a double level osteotomy, normal knee joint-line orientation was preserved and they showed in a computer model that the tension of stabilizing ligaments (i.e. collateral ligaments) remained normal after correction.
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