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A similar observation was made in a porcine model of spontaneously regressing melanoma in which MiTF was noted to be significantly downregulated during the regressive phase of the melanoma and upregulated during the progressive phase suggesting a central role for this protein in melanoma biology [92].

In another study [ 4], increased thickness of the subchondral bone occurred prior to any histologic evidence of cartilage degradation in a model of spontaneously occurring knee OA.

Recently, RANKL was reported to participate in osteoclast formation in a model of spontaneously developing erosive arthritis in the mouse [ 30].

Using an orthotopic murine model of spontaneously metastasising osteosarcoma, we show for the first time that systemic delivery of PEDF is capable of restricting the size of established primary and secondary osteosarcoma.

Contrary to the NO-deficient model of hypertension, studies experimenting with the genetic model of spontaneously hypertensive rats produced inconsistent results regarding the role of NO and ED in the development of hypertension.

In conclusion, the results of the present study demonstrate that a metastasis-suppressive CXCR4-blocking strategy is effective in an intratibial mouse model of spontaneously metastasizing, CXCR4-expressing OS.

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In this model of anesthetized, spontaneously breathing rats, we considered the effects of acid alone, in the absence of particulate matter, which is commonly a component of aspirated fluid in humans.

We evaluated the use of logistic regression to model the probabilities of spontaneously reported vaccine event pairs being adverse reactions following immunization (ARFI), using disproportionality and unexpectedness of time-to-onset (TTO) distributions as predictive variables and the presence of events in the global product information as a dependent variable.

In the BioBreeding diabetes prone (BB-DP) model of T1D, rats spontaneously develop the automimmune disease due to genetic susceptibility.

The best validated animal model of ADHD, the Spontaneously Hypertensive Rat (SHR), shows pronounced overactivity, impulsiveness, and deficient sustained attention.

The present study therefore investigated effects of maternal separation in a rat model of ADHD, the spontaneously hypertensive rat (SHR).

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