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DNA copy number and gene-expression analysis in MGUS and SMM have found similar abnormalities to MM, however they have failed to generate a robust and clinically useful model of progression to MM4,17,18,19,20.
These technologies led to identification of mechanisms of tumorigenesis that challenge the current multistep model of progression to EA. Newer, cost-effective technologies create opportunities to rapidly translate the analysis of DNA into tools that can identify patients with BE at high risk for cancer, detect dysplastic lesions more reliably, and uncover mechanisms of carcinogenesis.
The basic model of progression to ESRD included eGFR and triglycerides.
Previous reports suggest a model of progression from WDTC to PDTC and to ATC.
This hypothesis is in keeping with a stepwise model of progression of CRC.
The differences were sufficiently large that a prediction model of progression could be developed based on these values.
Similar(40)
First, we observe two models of progression from premalignant stage to MM.
The basic models of progression were built by starting with all known risk factors for DN.
Clinicians need to predict prognosis of Alzheimer's disease (AD), and researchers need models of progression to develop biomarkers and clinical trials designs.
These promise not only molecular profiles and signatures, but also models of progression that assimilate the heterogeneity and complexity of a decidedly continuous and nonlinear biological process.
Classification algorithms (Naïve Bayes and Logistic Regression) were used to develop prediction models of progression based on the initial lab data.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com