Both this compound and the dimethyl analogue 56 showed similar or decreased clearance rates in human liver microsomes relative to parent compound 3. Unfortunately, these compounds had higher mouse liver microsome clearance rates, which may make efficacy testing in a mouse model of infection problematic.
In addition, a ranking of the GDI sensitivities is used to identify an initial subset of problematic model parameters.
To purge the space of problematic models (e.g. those that were either incorrect or sensitive to initial parameter values), the space was reduced to models with SSEs that were less than twice the minimum SSE of the fitted models.
While these differences make direct comparisons of different model results problematic, the table nevertheless provides a useful overview of the range of potential welfare gains that may be possible from trade liberalization.
The co-variation detection model of joint attention seems problematic when we consider that many caregiver utterances do not refer to things that occupy the immediate attentional focus of infants.
But if we are to allow population genetic research to move forward, we need to recognize that adherence to this traditional model of informed consent is problematic.
However, there are aspects of the set point model of regulation that are problematic, particularly its inability to explain the increasing prevalence of obesity that has been observed in many societies over the past 40 years (Flegal et al., 2010; Ogden et al., 1997; Troiano et al., 1995; Kuczmarski et al., 1994).
(2) An image pre-processing is performed, where the image noise and uneven illumination background are removed by the Gaussian smoothing filter and top-hat filter respectively [ 20]. (3) Use of RGB model is problematic because these three intensities reflect both the absorption characteristics of the stains used and the amount to which those stains are present.
Apart from the problem of problematic business models, some platforms may even involve in "ponzi scheme" or fake p2p website.
In the process, a handful of problematic domain models (e.g. domains without fold-critical residues, domains with dominant proportion of remnant residues) were found.
