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One of the most commonly used animal models of NAFLD, genetic obesity, and metabolic syndrome is the genetic model of obese Zucker rats (fa/fa).
Recently, we confirmed DM-induced increase in acute mortality after MI in an animal model of obese type 2 DM (T2DM), Otsuka-Long-Evans-Tokushima Fatty rats (OLETF).
We examined the therapeutic effect of NM-3 on long-term renal alterations in db/db mice, a model of obese type 2 diabetes [ 27].
More recently, it was shown that DHEA reduces body weight and epididymal fat in a murine model of obese type 2 diabetes (18).
In the same way, RSV minimizes hyperglycaemia in diet-induced obese and diabetic mice [ 7], and dyslipidemia in the experimental model of obese Zucker rats.
The results from the studies of Teixeira de Lemos et al., above mentioned [ 33, 34], clearly demonstrated the anti-inflammatory capacity of swimming exercise training in the ZDF rat, a model of obese T2DM.
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The study authors have developed realistic 3-D "phantoms," or computer models of obese men and women that can help technicians calculate how to achieve the clearest images of such patients at the lowest radiation doses.
There are reports about changed amino acids concentrations in animal models of obesity and obese humans [ 24, 25], however interpretation of this ex vivo finding in relation to these reports is not unequivocal.
Eleven Goto-Kakizaki (GK) male rats, a model of non obese type 2 diabetes and three non-diabetic GK female rats from our facility were used to study PGF expression in diabetic conditions.
Extra-mitochondrial ROS level is also increased in a model of T2DM (obese Zucker rat).
These results from diabetic patients were corroborated using an animal model of hyperglycaemic obese mice (Lepob).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com