Here we provide the necessary theory to fit this case, using an approach that combines state-space models of nutrition with Tilman's models of resource exploitation (Tilman 1982, Resource Competition and Community Structure, Princeton Princeton University Presss).
We show how a combination of mixture design theory and state-space models of nutrition (the Geometric Framework, GF) can be used to derive a 5-step protocol for multi-criterion diet optimisation.
Developments in agent-based modelling, state space modelling of nutrition and multi-scale modelling of landscape ecology provide the components for a new synthesis in nutritional ecology linking the nutritional biology of individual organisms to population- and community-level processes across multiple scales within an evolutionary context.
While it would be desirable that such enteral access be provided within a broader multi-disciplinary model of specialized nutrition support, in the current climate of a tightening health care economy that may be counsel for perfection.
A logic model for nutrition interventions at point-of-sale and population health is shown in Figure 1.
The Simulator of the Human Intestinal Microbial Ecosystem (SHIME®) is an in vitro system proven to be a very useful model for nutrition studies, in terms of analysis of the intestinal microbial community composition [ 14- 16].
Detailed a priori food characterization, with respect to covariates influencing gastric emptying (i.e., through the incretin effect itself), intestinal transit and absorption, integrated within a reliable mechanistic model describing effects of nutrition could likely improve predictions of meal absorption.
Despite being largely studied as models of equine nutrition, few published data exist on actual nutritional requirements of Miniature horses.
For studies in whole organisms, the amount of the extract used must fall within a range that could reasonably be expected to be achieved safely in humans, whether the study involves human subjects or animal models of human nutrition, or in animals if they are the specific target for a putative health benefit.
