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These data imply that significant changes in Env spike structure are dependent upon precursor gp160 cleavage and are consistent with a restricted-binding-to-Env model of neutralization.
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In a mouse model of BoNT neutralization, the FP increased the potency of single and double antibody combinations in BoNT neutralization.
In a preclinical model of melanoma, neutralization RANKL by its decoy receptor osteoprotegerin markedly reduced bone metastases.
A mouse model of CCL2 neutralization showed that metastasis is inhibited due to retention of monocytes in the bone marrow.
In contradiction to the most commonly held model of antibody-mediated neutralization, Fab17-IA does not induce a conformational change in the HRV-14 capsid.
The resulting model of the inverse neutralization equation then serves as the component in a Wiener model controller that linearizes the pH process.
These results together support the model that the enhancement of neutralization in vivo required biotin-dependent interaction of the cloned mAbs with the FP and adherence of the FP-containing complexes to the surface of the RBCs (Figure 1a).
Neither Igm nor IgG appeared to be more capable of neutralization in this model.
Unfortunately, despite successful treatment in animal models, antibody neutralization of individual components of this inflammation has not proved beneficial for the majority of patients in clinical sepsis trials [ 3].
While the model of pro-apoptotic activation or neutralization by anti-apoptotic members are still incompletely known, recent findings have shown that BCL-2 ovarian killer (BOK), which displays a high sequence similarity to BAX and BAK, engages the mitochondrial apoptotic pathway independently of BAK/BAX [52].
For example, in the mouse model of multiple sclerosis, in vivo neutralization of IFN-γ resulted in exaggerated immune response and central nervous system immunopathology [27].
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