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We wished to develop a robust model of nasal CPAP in preterm lambs delivered at a less mature gestation (131 to 133 days) from ewes receiving general anaesthesia.
In this study, we sought to develop a robust model of nasal CPAP in preterm lambs 131 to 133 days gestation.
Rahmel and co-workers recently described the first authentic animal model of nasal CPAP applied from birth, using short binasal prongs in newborn preterm lambs at 136 days gestation [12].
Develop a model of nasal allergen induced Eustachian tube dysfunction (ETD) in a rat and investigate the role of immune modulatory oligonucleotides (IMOs) in the prevention of nasal allergen induced ETD.
The mutants identified in the 1st round screen with the OM model were "re-screened" in a murine model of nasal colonization with the same mutant pools used for the 2nd screen in the OM model (Fig. 3A).
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Problem: The objective of the research was to develop accurate numerical models of nasal airflow using computational fluid dynamics (CFD), a computer-based flow modeling technology widely used in engineering, to improve understanding of nasal airflow with a view to developing a method to assist in planning of nasal surgery.
Previously, we developed a nasal colonization model of porcine nasal mucosa explants to identify molecular traits involved in nasal MRSA colonization of pigs.
In an animal model, measurement of nasal potential difference correlated with alveolar fluid clearance [ 10].
A design-of-experiments (DOE) based formulation screening employing an in vitro tissue model of human nasal epithelium was used to assess drug permeability, tight junction modulation, and cellular toxicity.
The BfR value of 0.1 ppm is not derived solely based on sensory irritation, but rather incorporates considerations of cytotoxicity, cell proliferation, and the biologically based dose-response model for nasal tumors (none of which are relevant to sensory irritation), even while acknowledging that the epidemiological findings for nasal cancer were not causal.
We tested on a ΔF508/ΔF508 mouse model whether treatment of nasal epithelium with one of the pocket 2 molecules leads to correction of CFTR-related Cl− secretion by measuring nasal potential difference changes (Δ VTE) (Sermet-Gaudelus et al, 2010).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com