Sentence examples for model of mutant from inspiring English sources
Deletion of HDAC6 in a mouse model of mutant superoxide dismutase 1-linked amyotrophic lateral sclerosis is also neuroprotective, as reflected by the extended life span of mice and increased motor axon integrity [ 48].
13 Furthermore, by using an inducible mouse model of mutant Kras-driven lung cancer, Downward and colleagues showed that loss of Kras-p110α binding leads to long-term tumor stasis and partial regression.
Instead, the adaptive fate of populations of naked molecules would have been more accurately described by the quasispecies model of mutant distributions, which was introduced in the 1970's by Eigen [ 1- 3].
Although the detailed, mechanistic model of mutant Htt aggregation is not well-understood, a general, nucleated growth model of Htt exon 1 aggregation has emerged in the literature that accounts for the nonfibrillar globular structures and fibers observed by AFM and EM.
However, using a panel of fluorescently tagged variants of SOD1 in a cell model of mutant SOD1 aggregation, we demonstrate that the interactions between mutant and WT SOD1 in aggregate formation are not simply a co-assembly of mutant and WT proteins.
In this article, we considered a stochastic model of mutant-frequency evolution that can be used to infer the effective population size, selection coefficient, and mutation rates from temporal allele-frequency data using the method of maximum likelihood.
While XPO1 knockdown enhanced toxicity in some models of mutant C9orf72-related ALS/FTD24,25, XPO1 inhibition by SINE compounds mitigated toxicity in others22.
Functional studies in cellular and animal models of mutant alleles provide direct evidence for neuronal hyperexcitability as one cellular mechanism underlying headache or aura in FHM [9].
These new mouse models of mutant EGFR-dependent lung adenocarcinomas provide insight into clinical observations.
Molecular models of mutant enzymes were generated using SYBYL Tripos AssociatesSt . Louisis, MO).
Computational modeling of mutant protein structures when compared to WT kinesin showed substantial differences in conformational flexibility and ATP-binding efficiency.
