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Together, these observations support a model of motility in which regions of the cell edge exhibit one of a limited number of motility modules that, together, determine the overall motility function.
Thus, we designed a simpler model of motility, in which cell movement is implicitly tied to the survival of new cell progeny.
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Thus, the quantitative characterization of spreading motility modules can provide an important aid in comparing mathematical models of motility [54] to experiment.
Upon entering the female reproductive tract (or physiological media), sperm begin to manifest a model form of motility.
The hypothesis of discrete motility modules is consistent with our proposed model of hierarchical motility regulation [32].
Taken together, these data strongly indicate that the mode of motility employed by neutrophils in interstitial tissues is consistent with a previously described model of amoeboid motility [16], characterized by high speed adhesion-independent movement associated with a low degree of cytoskeletal organization and a lack of discrete focal contacts.
This concept can simplify biophysical modeling of cell motility by viewing the process as a sum of currently active motility modules.
This idea of relating the number of adhesions to the drag coefficient has been used in other models of cell motility [67] [69].
We also adjusted the models of sperm motility for duration of time between ejaculation and analysis of the sample.
Cellular Potts models have been used to simulate two-dimensional (2-D) models of cell motility in fish keratocytes [ 12] and amoebae [ 13].
Large-scale PPI screens have also revealed interactions between novel and known components of two models of bacterial motility, namely Campylobacter jejuni and Helicobacter pylori (Rajagopala et al., 2007).
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