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In the experimental model of MAS, intratracheal budesonide followed by the intravenous administration of aminophylline improved the lung functions more effectively than aminophylline alone [ 53].
Similarly, in a rabbit model of MAS, GCs already significantly improved several respiratory parameters within 30 min after the administration [ 50, 51].
In a rabbit model of MAS, the repetitive administration of dexamethasone 0.5 and 2.5 h after meconium instillation suppressed inflammation and enhanced gas exchange more effectively than a single dose administered 0.5 h after meconium [ 50, 52].
It corresponds well with our findings in the rabbit model of MAS, where intratracheal budesonide improved gas exchange and reduced lipid and protein peroxidation in the lung tissue more effectively compared to dexamethasone.
In a rabbit model of MAS, the slow intravenous administration of one dose, but especially of two doses of dexamethasone, was associated with acute changes of blood pressure, heart rate and heart rate variability within 5 h of treatment [ 52, 54].
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Confidence in the model of MA, and in the results of the studies, would be increased if it was possible for authors to explain why certain acu-points, as opposed to others, or even any, have anticipated effects on biomedical mechanisms.
The deterministic models of Ma et al. 2005 [ 32], Ramalingam et. al 2007 [ 37] and Ciliberto et al 2005 [ 29] are based on molecular mechanisms but none of these are really suitable for a stochastic approach, since the Gillespie algorithm assumes mass action kinetics and these models contain Hill or Michaelis-Menten functions in their rate laws.
Thus, it does not vary that much and can be assimilated as a constant model of 61 mA.
In multi-locus analyses, in male subjects the model of rs2106809 (ACE2), rs220721 (Mas), rs699 (AGT), and I/D (ACE) was significant (P = 0.043).
The four-locus model of rs2106809 (ACE2), rs220721 (Mas), rs699 (AGT), and I/D (ACE) scored nine of cross-validation consistency that was significant at the 0.05 level of P value.
In the label-free analysis, a model of progression to MA was built using 252 peptides, yielding an area under the curve (AUC) of 84.7 ± 5.3%.
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