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To test this hypothesis and to further elucidate the biology of these cancers, we generated a novel mouse model of malignant TGCTs.
We previously established an experimental model of malignant femoral tumors by transplanting VX2 carcinoma into the femur, and we have reported the efficacy of chemical embolic therapy, radiotherapy and hyperthermal therapy in treating the tumors in the model.
As a model of malignant tumor growth, Lewis lung carcinoma (LLC) was employed.
Furthermore, Treg accumulation is recapitulated in an experimental mouse model of malignant glioma [4], [5].
The mRNA expression for IL-17A in glioma was recapitulated in an immunocompetent mouse model of malignant glioma.
We used a mouse model of malignant mesothelioma, AB1-HA, to investigate T cell-dependent tumor resolution after chemotherapy.
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Array Comparative Genome Hybridization for Tumor Classification and Gene Discovery in Mouse Models of Malignant Melanoma.
Anti-tumor efficacy of paclitaxel-loaded pH-responsive expansile nanoparticles (Pax-eNP) was evaluated in vitro and in in vivo murine models of malignant peritoneal mesothelioma.
We have observed that overexpression of angiopoietin-1 (Ang1) in both subcutaneous and intracranial xenograft models of malignant astrocytomas reproduces many of the vascular features of these tumors, including glomeruloid bodies.
TargomiRs are minicells (EnGeneIC Dream Vectors) loaded with miR-16-based mimic microRNA (miRNA) and targeted to EGFR that are designed to counteract the loss of the miR-15 and miR-16 family miRNAs, which is associated with unsuppressed tumour growth in preclinical models of malignant pleural mesothelioma.
We demonstrated similar findings in tumor models that are less susceptible to virus infection including models of malignant peripheral nerve sheath tumors (in both subcutaneous and intraperitoneal locations) and osteosarcoma (Figures S5, S6, S7).
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