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Since the device will be implanted into a cochlea filled with lymph fluid in future, the basic characteristics in terms of vibration and acoustic/electric conversion are investigated both in the air and in the silicone oil which is a model of lymph fluid.
The establishment of highly metastatic cell lines, M3a2 and M4e, which are derived from a poorly metastatic parental cell line, 686LN, in a mouse model of lymph node metastatic, suggest that such intratumor heterogeneity may exist within HNSCC [19], [20].
In this study, we investigated the effects of Annexin A7 on HCC and lymphatic metastasis in a mouse model of lymph node metastasis by using the two mice hepatocarcinoma ascites syngeneic cell lines Hca-F and Hca-P with high and low lymphatic metastasis potential, respectively.
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Preclinical models of lymph node (LN) metastasis are fundamental to the study and design of new techniques for the diagnosis and treatment of LN metastasis.
Results of multiscale, stochastic modeling of various phenomena in immunology have been reported, for example, in host-pathogen interactions [ 39], the modeling of lymph nodes [ 40], and the resolution of inflammation by leukocytes [ 41].
Human MCF-7 breast cancer in nude mice and animal model of P388 lymph node metastases in Kunming mice were applied to investigate the therapeutic effects.
This study aimed to construct a preoperative predictive model of cervical lymph node metastasis using fluorine-18 fluorodeoxyglucose positron-emission tomography/computerized tomography (18F-FDG PET/CT) findings in patients with oral or oropharyngeal squamous cell carcinoma (SCC).
An animal foot pad model of melanoma lymph node metastasis was established.
Along similar lines, employing an agent-oriented approach, Riggs et al. [ 55] developed a two-dimensional (2D) model of a lymph node that captured various empirically observed features of T-cell and dendritic cell dynamics.
To consider the influence of the lymph fluid surrounding the OC model, FEM models of the lymph fluid in the SV, SM, ST, and subtectorial space were constructed, as shown in Figures 4 and 5 [ 1].
Disease marker concepts should be applied to trials of treatments for pre-invasive disease including DCIS and to models of sentinel lymph node assessment, where funding is limited and where long-term follow-up is required to obtain robust clinical data, but where we need a better understanding of the pathophysiological processes involved.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com