Exact(9)
To establish a novel and useful rabbit model of lumbar disc degeneration using microinjection of a fibronectin fragment.
In a previous study, doxorubicin was shown to decrease spinal fusion rates in a rabbit model of lumbar intertransverse process spinal fusion with autograft iliac crest bone.
Stride lengths have been previously reported in a rat model of lumbar radiculopathy using a foot-printing method [ 54].
McGill and Kippers [ 3] used an anatomically-detailed model of lumbar tissues to assess muscle and passive tissue loading during complete trunk flexion.
In prior work, mechanical hypersensitivity and gait compensations were found to follow unique time scales in a rat surgical model of lumbar radiculopathy [ 9].
We used a model of lumbar radiculopathy and behavioural and electrophysiological analyses to investigate whether sympathectomy could attenuate pain-related behaviour and alter the electrical properties of the DRG neurons.
Similar(51)
Four poroelastic finite element models of lumbar spinal segments L2-L3 with different grades of disc degeneration were developed.
Behavioral changes observed in pre-clinical models of lumbar radicular pain may relate to painful symptoms observed in human subjects.
Our data indicate gait characterization has value for describing early limb dysfunctions in pre-clinical models of lumbar radiculopathy.
Prior studies of rat models of lumbar radiculopathy have reported either normal gait characteristics based upon visual inspection [ 49- 53] or mild gait compensations based upon foot-printing methods [ 54].
Sequestration of TNFα via either an anti-TNF antibody or the soluble form of the TNF receptor is capable of modulating TNFα activity; moreover, this therapeutic strategy has demonstrated some promise in pre-clinical models of lumbar radiculopathy and peripheral neuropathy.
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