Sentence examples for model of leukemia from inspiring English sources

In our previous work in a xenograft model of leukemia, we compared two T cell manufacturing methods that are commonly used in adoptive immunotherapy clinical trials, CD3/CD28 Dynabead and OKT3/IL-2.

Similar ambivalent modes of action were identified recently for p21/WAF1 in a mouse model of leukemia [50].

B7-H1 partinipathe immunoescapeofscancerf cellsr cells and is also involved in the long-term persistence of leukemic cells in a mouse model of leukemia.

The question arises: Is it possible to translate the observations of DAC in this mouse model of leukemia to the clinical treatment of patients with leukemia?

Lastly, we demonstrate that MerTK inhibition sensitizes leukemia cells to treatment with chemotherapeutic drugs, and reduces their leukemogenic potential in a xenograft mouse model of leukemia.

This may reflect their origin from the BNML model of leukemia, considered reliable to judge the clinical efficacy of anti-leukemic drugs.

To explore this question, the researchers used mouse models of leukemia, engineered by transplanting human leukemia cells under the skin of immunocompromised mice.

Forristal CE, Brown AL, Helwani FM, Winkler IG, Nowlan B, Barbier V, et al. Hypoxia inducible factor (HIF -2alpha accelerates disease progression in mouse models of leukemia and lympHIF -2alpha not acceleratesnosis factor in human AML.

Program members have expertise in identifying oncogenes, defining basic mechanisms of neoplastic transformation in cell culture and murine models of leukemia, analyzing the biology of myeloproliferative neoplasms, developing novel immunotherapeutic approaches, conducting clinical trials of novel therapies, and investigating outcomes for stem cell transplantation as therapy of leukemia.

Here I review three noteworthy applications of fluorescent proteins in zebrafish: (1) analysis of kinesin motor function in the cleaving zebrafish embryo, (2) determination of the roles of semaphorins in axonal guidance, and (3) creation of transgenic models of leukemia and other cancers.

In mouse models of leukemia and melanoma, IDH mutants accelerated cell cycle transition by activation of the MAPK/ERK pathway and repression of tumor suppressors CDKN2A and CDKN2B (Chaturvedi et al., 2013; Shibata et al., 2011).