We have demonstrated this in isolated cardiomyocytes, as well as in a mouse model of ischemic cardiomyopathy.
When compared to other models of tissue ischemia such as coronary or cerebral artery ligation, femoral artery ligation provides for a simpler model of ischemic tissue.
In the pig model of ischemic cardiomyopathy, previously developed in our laboratory, MI induced by severe coronary stenosis, impacts on LV function, reducing ejection fraction (EF) from 60%to40%0% without however frank heart failure31, 32.
This formulation reduced the infarct volumes by more than 50% in a mouse model of ischemic stroke.
To evaluate the effects of allogeneic mesenchymal stem cells (MSCs) in a model of ischemic acute kidney injury (AKI).
Data of the present study indicate neuroprotective effect of MMF in the experimental model of ischemic stroke.
To investigate the role of iNOS in this process, a randomized, controlled study was designed using a classical rat model of ischemic spinal cord injury.
With an established model of ischemic retinopathy we found that calpain inhibitors, when administered in moderation, reduced architectural abnormalities, reduced vascular leakage, and most importantly reduced retinal hypoxia.
To clarify the role of BAD within the JNK pathway, a randomized, controlled study was designed using a rabbit model of ischemic spinal cord injury [5,8].
The authors used a 2 × 2 study design to compare ECMO versus CPR and epinephrine versus placebo in a porcine model of ischemic refractory ventricular fibrillation (VF).
Inhibiting protein phosphatase-1 through the overexpression of a constitutively active inhibitor-1 (I-1c) has been shown to reverse cardiac dysfunction in a model of ischemic HF.
