Sentence examples for model of ischaemic from inspiring English sources
The UCLBAL was efficacious in a porcine model of ischaemic acute liver failure using pigs of adequate size to reflect the same liver size as expected in man (25.2 34.4 kg pig weights, 0.88 1.71 kg liver weights, n = 25).
A clinical sized BioArtificial liver machine (UCLBAL) was prepared and tested in an animal model of ischaemic acute liver failure, using GMP-compatible methodology suitable for use in man as a cell therapy.
In a mouse model of ischaemic stroke, regulatory T cells infiltrate the injured brain in response to the chemokines CCL1 and CCL20 and suppress excessive astrogliosis via the production of amphiregulin.
Additionally, a pre-clinical model of ischaemic retinopathy was used to evaluate the effects of high- and low- dose simvastatin in vivo.
Here, Stuart Allan and colleagues selectively eliminated haematopoietic-derived IL-1 in a chimeric mouse model of ischaemic brain injury.
Repetitive intracoronary infusion of microparticles induces severe myocardial dysfunction and has been used as an experimental model of ischaemic heart failure.
van der Spoel, T. I. et al. Human relevance of pre-clinical studies in stem cell therapy: systematic review and meta-analysis of large animal models of ischaemic heart disease.
Previous work in other models of CNS injury also showed that a baclofen treatment can inhibit caspase activation (model of kainic-acid-induced seizure in rats:29; models of ischaemic brain injury in rats:27,31; model of chemical hypoxia in retinal ganglion cells in rats:66).
Specifically, in vivo approaches have demonstrated that administration of Notch ligand to stimulate the neural stem cell niche has been of direct therapeutic benefit in animal models of ischaemic brain injury [68] and Parkinson's disease [69].
Importantly, it has been demonstrated that administration of exogenous human recombinant rHuEPO to pre-clinical models of ischaemic injury can significantly reduce neurodegeneration by preventing neuro-glial apoptosis [4].
In vivo visualization of necrotic tissue may also provide a quantitative index for evaluating the antinecrotic effect of drugs in development in animal models of ischaemic heart disease.
