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In fact, our results agree with this model of internalization since the activated CCR2B receptor requires FLNa interaction to initiate internalization and probably the link to actin fibers.
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The function of Eps15 can best be described using a model of EGFR internalization.
The values of the parameters intk2 and reck1 are from a model of receptor internalization and recycling without insulin [ 34].
This model of virus internalization by way of the hepatocellular tight junction 26 is consistent with our earlier observation that hepatoma polarization restricts HCV entry.
This coupling of slow and fast processes in our system allows us to develop a simplified model of toxin internalization using the well-known framework of Quasi-Steady-State Approximation (QSSA); see [ 24– 28, 37] and refs therein.
f 1 = i n t k 2 ⋅ R − r e c k 1 ⋅ R e n f 2 = i n t k 2 ⋅ I R f 3 = i n t k 2 ⋅ I 2 R f 4 = i n t k 1 ⋅ R p − r e c k 1 ⋅ R p e n f 5 = i n t k 1 ⋅ I R p f 6 = i n t k 1 ⋅ I 2 R p The value of the parameter intk1 was directly taken from a model of receptor internalization and recycling at high insulin concentrations [ 34].
Our overall findings are in agreement with previous studies utilizing experimental cellular models of bacterial internalization, using either intracellular or facultative intracellular pathogens.
It should be stated that the model parameters for receptor internalization and recycling are from the same source as the experimental data sets in Figure 4. Backer et al. took the experimental data sets to estimate the parameters for two separate models of receptor internalization and recycling at 100 nM insulin as well as without insulin [ 34].
As recent as 2012, investigators proposed a model of C. jejuni internalization involving caveolae structures [ 18].
This animal model showed internalization of the light chains utilizing caveolae followed by trafficking to the mature lysosomal compartment where fibrils were formed.
This indicated that the former study on the stages model and Also, the theory of internalization that discussed companies go abroad to exploit their internally developed knowledge no longer applied to all ventures (McDougall et al. 1994).
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