Sentence examples for model of infectivity from inspiring English sources
In the context of assays that could be used to detect infectivity of natural and farm soils, it is important to acknowledge another crucial limitation of the presented cell model of infectivity.
The cells provide a good model of infectivity uptake, prion propagation, cell-to-cell spread and clearance, although unlike neurons in an in-vivo infection they are able to tolerate prion infection without undergoing cell death.
We made the following assumptions: - We used realistic modelling of infectivity based on experimental infection viral shedding data [ 25].
A recent review of animal models for infectivity of Q fever concluded that to estimate human infectivity pathogen aerosol challenge data was required [ 20].
Therefore, the infectivity and pathogenicity of genotype 4 HEV in rabbits was much lower than seen in non-human primate models of infection.
The length of the incubation period may be due to cumulative exposure (total dose of infectivity model) or to an independent combination of individual challenges.
Using the rodent model of P. yoelii, the infectivity of cryopreserved sporozoites was reduced by more than a factor of seven compared with fresh sporozoites when both were injected intravenously.
In light of the prionuria detected in CWD and in models of scrapie, further investigations of infectivity in body fluids in other protein folding diseases may be warranted in the event that prion diseases are not the only infectious proteinopathies.
Our results show that the dnIGE model can provide unbiased heritability estimates of infectivity, therefore fully capturing genetic variation in this trait from longitudinal disease records.
Additionally, although our methodology works best for infection data with high disease prevalence, the dnIGE model can also provide reliable estimates of infectivity and susceptibility genetic parameters when fitted to data with low disease prevalence, where information for inference is reduced.
Despite the epidemiologic evidence of bloodborne transmission in vCJD, bioassays performed on conventional rodent models failed to demonstrate the presence of infectivity in the blood (8 ).
