Sentence examples for model of human aging from inspiring English sources

We tested this hypothesis in a nonhuman primate model of human aging.

Each animal model of human aging has its inherent advantages and limitations, since no single model exactly reflects the age-related processes that occur in humans.

Based on recent findings on WS and HGPS, we suggest a model of human aging.

On the basis of the information available for WS and HGPS, we suggest a model of human aging.

Werner syndrome is considered to be a model of human aging and is characterized by baldness, cataracts in the twenties, atrophy of the skin, type II diabetes mellitus usually in the thirties, arteriosclerosis in the forties, and increased incidences of malignant cancers in the mid-forties [ 1- 3, 5].

Since affected tissues in age-associated disorders and in pathological aging are mainly of mesenchymal origin we propose a model of human aging based on mesenchymal stem cells (hMSCs) which accumulate prelamin A. We demonstrate that prelamin A-accumulating hMSCs have a premature aging phenotype which affects their functional competence in vivo.

A deficit in water maze performance reported here confirms numerous prior studies supporting the rat as a model of human age-related cognitive decline (reviewed in [60]).

Dr. Norton W. Milgram, a behavioral neuroscientist at the University of Toronto, and Dr. Carl W. Cotman, a neurochemist in the Institute for Brain Aging and Dementia at the University of California at Irvine, have been studying old dogs as models of human aging.

We wanted to assess whether the miRNAs that we found in human serum were also expressed in other long-lived species that are used as models of human aging [ 26].

In the present work we further explore the senescent phenotype of pre-hMSCs previously detected by our group, and we propose an experimental model of early onset of human aging based on the induced accumulation of prelamin A in adult human stem cells (such as hMSCs).

The ability to detect a large number of biologically plausible gene expression changes support the use of CD14+ monocytes, a readily accessible cell population, as a model for further investigations of human aging, including the potential decline of autophagy and mitochondrial biogenesis with age.