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Large amounts of unmeasured anions were generated after hemorrhage in this highly standardized model of hemorrhagic shock.
A Wistar rat model of Hemorrhagic shock (HS) was used.
The porcine model of hemorrhagic shock has been previously described [15].
An animal model of hemorrhagic shock has been used to evaluate blood cells as a marker of organ mitochondrial function [34].
The aim of our study was to compare poly(ADP-ribose) polymerase (PARP) activity levels in a porcine model of hemorrhagic shock and resuscitation.
This study is designed to determine the effects of delayed fluid resuscitation on the hemodynamic changes and cytokine responses in a rat model of hemorrhagic shock.
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Rizoli and coworkers showed in animal models of hemorrhagic shock that hypertonic fluid prevents LPS-stimulated expression and activation of CD11b in the lung [34, 35].
In animal models of hemorrhagic shock, early (< 24 hours) changes in cytokine production are an index of the systemic inflammatory response syndrome.
There is evidence that systemic administration of minocycline reduces brain iron level and improves neurological outcome in experimental models of hemorrhagic and ischemic stroke.
Despite the use of clinical relevant models of hemorrhagic shock (in particular by Poloujadoff et al. [20]), the experimental models are not able to reproduce exactly the conditions and multiple tissue lesions observed in real polytrauma patients.
This hypothesis was initially tested in experimental conditions, in animal models of hemorrhagic shock.
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