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Evidence for social anxiety and impaired social cognition in a mouse model of Fragile X syndrome.
A mouse model of fragile X syndrome exhibits heightened arousal and/or emotion following errors or reversal of contingencies.
Suvrathan, A., Hoeffer, C.A., Wong, H., Klann, E. & Chattarji, S. Characterization and reversal of synaptic defects in the amygdala in a mouse model of fragile X syndrome.
Moon, J., Beaudin, A. E., Verosky, S., Driscoll, L. L., Weiskopf, M., Levitsky, D. A., et al. Attentional dysfunction, impulsivity, and resistance to change in a mouse model of fragile X syndrome.
The original guidelines (published in 2000) have been revised, replacing a stratified pre- and full mutation model of fragile X syndrome with one based on a continuum of gene effects across the full spectrum of FMR1 CGG trinucleotide repeat expansion.
Indeed, the first specific therapeutic treatment for a condition with co-morbid ASD symptoms was reported using a Drosophila model of fragile X syndrome [37].
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Galloway, J. N. et al. CGG repeats in RNA modulate expression of TDP-43 in mouse and fly models of fragile X tremor ataxia syndrome.
In previous studies using mouse models of fragile X, Bear and others discovered that the loss of this gene results in exaggerated protein synthesis at synapses, the specialized sites of communication between neurons.
Giving access to 3-D models of fragile archaeological remains through a seamless database improves students' learning experience but also can help researchers working at remote sites if they need a fast reference point, Seetah said.
For instance, increased numbers of dendritic spines, which also appear longer and thinner than normal, were described in patients with Fragile X syndrome and were subsequently confirmed in mouse models of Fragile X syndrome [3].
It also addresses shortcomings in the current mouse models of Fragile X spectrum disorders.
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