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Here we review recent work on the development and application of a deterministic mathematical model of filariasis transmission, to show how models of parasite transmission will help resolve the key currently debated questions regarding the ultimate effectiveness of the global strategy to control filariasis.
Figure 2A shows how predictions of a mathematical model of filariasis transmission [24], [25], [31] allow an examination of the usefulness of implementing a 5-year MDA strategy with DEC/ALB or IVM/ALB that has as its target either parasite elimination and eradication (set to be around 0.5% mf prevalence here [5]) or disease control (3.55% mf prevalence).
Litomosoides sigmodontis is a well-established model of filariasis in the mouse, with the vector being the mite Ornithonyssus bacoti.
Although L. sigmodontis is a well-established model of filariasis in vertebrates, its relationships with the invertebrate vector are mainly unknown.
In a study on L. sigmodontis model of filariasis, it has been proposed that the cell recruitment depends on many factors like host susceptibility, immune response, and cell adhesion properties [ 49].
Litomosoides sigmodontis (Chandler, 1931) is a well-known murine model of filariasis with adult worms residing in the pleural cavity of its rodent host [ 2] and blood microfilariae [ 3].
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In animal models of filariasis 50 and schistosomiasis 51, 52, Treg phenotype populations develop following infection, whilst in infection with the murine gastrointestinal nematode H. polygyrus 17, functional regulation by CD4+CD25+ T cells suppresses the bystander response to an allergic provocation.
Here, we use an age-structured dynamical model of lymphatic filariasis transmission to show how a quantitative understanding of the dynamic processes underlying infection persistence and extinction is key to evaluating the eradicability of this macroparasitic disease.
The form of filariasis known as filariasis malayi closely resembles bancroftian filariasis in its symptoms and pathological changes; it is caused by Brugia malayi, found chiefly in the Far East.
The prevention of filariasis relies heavily on insecticides and insect repellents.
On the other hand, the treatment of filariasis constitutes one of the success stories of mass drug administration (Global Programme to Eliminate Lymphatic Filariasis - GPELF) with decreased primary infections following the global programs of eradication [43].
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com