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GOMER (generalizable occupancy model of expression regulation) calculates binding probabilities on the basis of position weight matrices, and incorporates the effects of cooperativity and competition by explicit calculation of coupled binding equilibria.
Using the expression levels, we build a statistical model of expression for each probe set, based on an assumed bimodal distribution, that accounts for the two states of an expressed gene: Up and Down.
Genes that are misexpressed in hybrids compared to each species follow a semi-dominant model of expression behavior because most genes have an intermediate level of expression in hybrids.
First, for misexpressed genes in hybrids the overwhelming preponderance of misexpressed genes follow a semi-dominant model of expression behavior because hybrid expression is intermediate and/or additive compared to expression differences between the two species (Table 2).
These results suggest a general pattern of intermediate expression in hybrids and are consistent with a semi-dominant model of expression difference even despite the strong asymmetrical pattern of misexpression in hybrids compared to the two parental species.
In short, stabilizing selection model of expression divergence is consistent with the nearly neutral model.
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We further computed differential expression patterns between NAT and tumor samples (Supplementary Data 4) and divided all DEGs between healthy, NAT, and tumors into nine models of expression change: upregulation/downregulation/stable between healthy and NAT (A:H Adjacent:Healthy) and between NAT and tumor (T A Tumor Adjacent) (Fig. 4a).
Defining models of expression evolution is an important (and challenging) future goal.
Despite its relevance, however, statistical modeling of expression quantitative trait loci (eQTL) has not received the attention it deserves.
OPSM approach is based on the formulation of a probabilistic model of the expression data.
He's also the very model of concise expression when a point demands it.
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models of expression
modes of expression
examples of expression
model of collaboration
model of predictability
model of production
model of success
model of precision
model of rehabilitation
model of inclusiveness
model of dysfunction
model of patience
model of consistency
model of collegiality
model of conservatism
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