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In the present study, we used a mouse model of embryonic pig tissue implantation to define the role of host Factor VIII in controlling the final size attained by the implant.
The tetrapod limb has long been used as a model of embryonic development in three dimensions.
More recently, the "hourglass" model of embryonic conservation was proposed, where animals are most similar at an intermediate stage of embryogenesis called "the phylotypic stage," and earlier and later stages are more divergent (Duboule 1994; Raff 1996).
In an in vitro mouse model of embryonic development, inhibition of autophagy prevented the upregulation of two important cell-surface engulfment signals – phosphatidylserine and lysophosphatidylcholine – in cells destined to die (Ref. 101).
We next assessed the ability of TALEs to regulate target gene expression during development using the mouse EB differentiation system, which has been validated as a useful and tractable in vitro model of embryonic haematopoiesis (Keller et al., 1993).
In one well-studied model of embryonic Drosophila neurogenesis, specification of NB identity within the ventral neuroectoderm (vNE) depends on the dorsoventral and anteroposterior axial patterning systems to generate a highly regionalized vNE that has been likened to a Cartesian coordinate map (for reviews, see Skeath, 1999; Skeath and Thor, 2003).
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Comparison and synthesis of molecular models of embryonic laterality.
Until his death in June 1954, Turing used the Ferranti Mark I at Manchester for developing mathematical models of embryonic growth, an exciting new field of research known as morphogenesis or "the development of shape and form in living things".
In experimental models of embryonic hypoxia, it has been found that chronic hypoxia results in growth restriction, aortic remodeling, sympathetic hyperinnervation, and left ventricular (LV) pump dysfunction in the embryo [8] [10].
Thus, models of embryonic wound healing will evidence gene regulations that are crucial for the healing process and independent from the perturbation induced by immunocompetent cells.
Animal models of embryonic immobilisation confirm that endochondral ossification and joint formation are profoundly affected by altered movement (indicated in Figures 2 and 3, respectively; also described in supplementary Table i).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com