Sentence examples for model of dosage from inspiring English sources

The model of dosage balance also provides an explanation for Xenopus laevis possessing three slightly different GAPD isoenzymes [Swiss-Prot: P51469, GenBank: BC043972, GenBank: BC048770].

The retention of GAPD-3 by certain species of teleosts agrees with the model of dosage balance proposed by Papp with colleagues [ 65, 68].

The canonical evolutionary model of dosage compensation invokes stabilizing selection to maintain ancestral expression levels of sex-linked genes in the heterogametic sex as gametologs erode from the W (or Y) (Ohno 1967; Charlesworth 1978; Mank 2009).

These data are in agreement with the current model of dosage compensation that implies a role of the MSL complex in facilitating transcription elongation (Fig.  4a) (Henikoff and Meneely 1993; Smith et al. 2001).

Integration of the recent data concerning copurification of nuclear pore components and exosome components with MSL proteins into the elongation model of dosage compensation may help to conceptualize how this might be achieved (Fig.  4b).

However, Xiong and colleagues found there is no dosage compensation of the active × chromosome and revised the current model of dosage compensation with RNA sequencing, revealing that with application of next generation sequencing technologies, the mechanism of gene expression regulation and its related pathological phenotypes in human aneuploidy eventually can be discovered [ 24- 26].

Finally, models of dosage form disintegration and drug release by single fibers and fibrous dosage forms are developed.

However, the common theme among all model systems of dosage compensation, which have been analyzed at the molecular level, is their regulation at the level of chromatin.

The methylation and expression levels were taken as phenotypes and a linear model of allele dosage, with age and gender as covariates, was tested using PLINK [ 24].

The gene-by-gene model of avian dosage compensation means that for some genes the precise expression level might be more critical than for others, for example, because their fine-tuned regulation is essential for function in networks or pathways.

Read closely on the amount of dosage.