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To define the function of BRMS1, a murine xenograft model of distant NPC metastasis was constructed.
Considering the role of IGFBP-rP1 in controlling EMT and migration in vitro, we extended our study to an immunocompetent mouse model of distant metastasis.
Although this hypothesis focuses on archaea and E. coli, the model of distant gene transfer as a major contributor of "new" virulence genes to pathogens or potential pathogens has broad applicability to a large number of pathogenic systems.
For this aim, we adapted (see Appendix S1 for details) the model of distant species hybridization without genetic introgression between parental species that we have recently developed (Quilodrán et al. 2014).
As another model of distant metastasis, we injected AsPC-1 cells into the left leg and the peritoneal cavity, and again, when tumour mass was established on the left leg, 1 × 10 PFU of adenovirus was injected once into the tumour.
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Briefly, this model incorporates data from Earth-observing satellites, including spatially dependent snow and cloud cover, surface temperature, and gas mixing ratio profiles, as input to a spatially and altitudinally resolved radiative transfer model of a distant Earth-like planet.
The image that opens the exhibition, a horizontal human face, surreal -- almost Bunuel-like -- is surmounted by models of a distant but ideal village of one's youth.
Similar observations were made for the joint modelling of the distant SNPs, the non-synonymous MC4R polymorphisms and the mutations (Table 5; right panel).
At this year's Intel Science Fair, Henry Lin of Shreveport took home a $50,000 award for his work on modeling the behavior of distant clusters of galaxies.
VEGF and HIF1-alpha were not included in the RTOG modelling of risk of distant metastases because an earlier RTOG study failed to demonstrate a significant association of VEGF with any survival outcomes following radiotherapy [ 34].
Pollack et al. recently modelled the risk of distant metastases using expression of the above 5 candidates plus the apoptotic proteins Bcl-2 and Bax with competing risks hazard regression, adjusting for age, PSA, the Gleason score, T-stage, and treatment [ 33].
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