We demonstrated that a 177Lu-labelled variant of mAb chCE7 showed high efficacy in a xenograft model of disseminated ovarian carcinoma [25].
We designed a hollow fiber system model of disseminated intracellular tuberculosis with co-perfused three-dimensional organotypic liver modules to simultaneously test for efficacy and toxicity.
The experiments were designed to observe the target effects in a model of disseminated human lymphoma and in cells by flow cytometry and cell-based immunoreactivity assays versus appropriate control cells.
The impact of the observed difference in vitro MICs was investigated in an immunocompromised murine model of disseminated aspergillosis.
Of note, the VR spaces which appear as the main anatomical site involved, radiologically, during cerebral cryptococcosis are also the site of brain invasion associated with fungemia in a relevant murine model of disseminated cryptococcosis [48] [50].
Genetic modifications to NSCs by our laboratory and others have shown 70 90% therapeutic efficacy following intracranial administration of NSCs in animal models of orthotopic glioma, medulloblastoma, and melanoma brain metastases, and following intravascular administration in a mouse model of disseminated neuroblastoma [4], [6], [7], [8], [9], [10], [11].
This effect was previously observed in an animal model of disseminated mucormycosis [ 105].
In contrast, the expansion of a CD4+CD25+ population, containing Treg cells, inhibited macrophage-mediated innate clearance of C. albicans in a murine model of disseminated infection 25.
In a preclinical model of disseminated prostate cancer, it was shown that treatment with a neutralizing antibody against PDGFRα inhibited the growth of skeletal metastases [ 189, 190].
We used a well-established murine model of disseminated mycobacterial infection and demonstrated that disruption of the Cd36 gene confers an altered susceptibility phenotype.
