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We used a mouse model of disrupted VEGF isoform expression that eliminates the predominant brain isoform, VEGF164, and expresses only the diffusible form, VEGF120.
These findings support a model of disrupted thalamic connectivity in ELS and trauma-related negative affect states, and underscore the importance of a transdiagnostic, dimensional neuroimaging approach to understanding the sequelae of trauma exposure.
Taken together results of our studies support a model of disrupted protective function of paraspeckles triggered by FUS mislocalization and aggregation (Fig. 9).
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Part of that includes starting young and adopting the tech model of disrupting large, systemic institutions.
Models of disrupted ghrelin signalling can show complex energy homeostasis-related phenotypes.
Haploinsufficiency of Sim1 is associated with hyperphagic obesity and increased linear growth (Kublaoui et al., 2006; Michaud et al., 2001), closely resembling the phenotype of agouti yellow (A y) and Mc4r null mice, two classic models of disrupted hypothalamic melanocortin signaling.
Bout length reductions were greater during the night (the active phase for mice) than during the day, which does not model the human condition of disrupted sleep at night (the inactive period).
Vaginal application of this model microbicide resulted in foci of disrupted epithelium detectable by confocal endomicroscopy.
Cook and Tanner in [20] represented a full gate-to-gate model which includes re-accommodation of disrupted passengers with missed connections due to delays.
The idea of disrupted internal model learning is particularly intriguing in relation to the cerebellum-autism connection.
In this report, we describe a mouse model that confirms the critical role of disrupted axonal transport in the pathogenesis of motor neuron degenerative disease.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com